As educational technology continues to evolve, we are beginning to see new mutations that are reshaping the landscape of teaching and learning. From the rise of blended learning models to the use of artificial intelligence and adaptive learning algorithms, these mutations are changing the way educators approach their work and the way students engage with course material. However, as with any mutation, there are both risks and opportunities associated with these changes. Educators must navigate this rapidly changing terrain with care, considering the potential benefits and drawbacks of each new development and seeking out evidence-based approaches to inform their teaching practices. By doing so, they can ensure that these mutations in educational technology are harnessed to enhance learning outcomes and improve the educational experiences of all students.